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gov number, NCT00160108. Results The rate of adherence to a study diet was 95. Figure 2 Total 24-Hour Urinary Nitrogen Excretion and Changes in Body Weight. Methods We enrolled overweight adults from eight European countries who had lost at least 8% of their initial body weight with a 3. Methods Study Protocol The study design, methods, and procedures have been described in detail previously. Figure 2 Weight Changes during 2 Years According to Diet Group. Media in This Article Figure 1 Enrollment of the Participants and Completion of the Study. Participants were randomly assigned, in a two-by-two factorial design, to one of five ad libitum diets to prevent weight regain over a 26-week period: a low-protein and low-glycemic-index diet, a low-protein and high-glycemic-index diet, a high-protein and low-glycemic-index diet, a high-protein and high-glycemic-index diet, or a control diet. Media in This Article Figure 1 Screening, Randomization, and Follow-up of Study Participants. The principal investigator at each study center collected the local data, which were entered into a data-registration system (EpiData) 12 and transferred to a central data hub. Abstract Background Trials comparing the effectiveness and safety of weight-loss diets are frequently limited by short follow-up times and high dropout rates. The overall study leaders, together with the principal investigator at each study center, designed the study. Article Activity 272 articles have cited this article Article The importance of the composition of a diet for the prevention and management of obesity is debated. Abstract Background Studies of weight-control diets that are high in protein or low in glycemic index have reached varied conclusions, probably owing to the fact that the studies had insufficient power.
) Full Text of Discussion. Methods Eligibility and Study Design We conducted the trial between July 2005 and June 2007 in Dimona, Israel, in a workplace at a research center with an on-site medical clinic. (ClinicalTrials. The Mediterranean-diet group consumed the largest amounts of dietary fiber and had the highest ratio of monounsaturated to saturated fat (P Full Text of Results. The more favorable effects on lipids (with the low-carbohydrate diet) and on glycemic control (with the Mediterranean diet) suggest that personal preferences and metabolic considerations might inform individualized tailoring of dietary interventions. 11 The study was conducted in eight European countries: Denmark, the Netherlands, the United Kingdom, Greece (Crete), Germany, Spain, Bulgaria, and the Czech Republic. We report here the results of the 26-week weight-maintenance intervention phase of the study. Conclusions Mediterranean and low-carbohydrate diets may be effective alternatives to low-fat diets. The groups did not differ significantly with respect to diet-related adverse events. 6% at 2 years. The participants were randomly assigned within strata of sex, age (below or above the median), BMI (below or above the median), history of coronary heart disease (yes or no), history of type 2 diabetes (yes or no), and current use of statins (none, The members of each of the three diet groups were assigned to subgroups of 17 to 19 participants, with six subgroups for each group. 3-MJ (800-kcal) low-calorie diet. The criteria for eligibility were an age of 40 to 65 years and a body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) of at least 27, or the presence of type 2 diabetes (according to the American Diabetes Association criteria 18 ) or coronary heart disease, regardless of age and BMI. 4% at 1 year and 84.
